Subfoveal neovascular membranes Eye Diseases Other retinal disorders
Conditions
Interventions
Radiotherapy at a total dose of 12 Gy versus control
Sponsors
Medical Research Council (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Target population aged 60 years or over, with subfoveal CNVM and diagnosis of ARMD confirmed by the clinical and angiographic examination
Exclusion criteria
Exclusion criteria: 1. Patients under 60 years of age 2. Those with vision worse than Bailey Lovie 1.0 3. Patients not wishing to be included in the study 4. Patients with unstable hypertension, diabetes or generalised vasculitides and or life-threatening disorder making three year survival unlikely.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Efficacy: distance visual acuity (ETDRS), near visual acuity (ETDRS), contrast sensitivity (Pelli Robson), reading speed, ophthalmoscopy, slit-lamp biomicroscopy, fundus photography, fluorescein angiography, generic quality of life questionnaire, condition-specific quality of life questionnaire, assessment of tear film, lens clarity, retinal vasculature and (electrophysiology to monitor retinal and optic nerve function [Belfast only]) 2. Health economics: evaluation of treatment costs, care costs, costs on patient and family | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
United Kingdom
Outcome results
None listed