Acute respiratory failure Respiratory Acute respiratory failure
Conditions
Interventions
Diaphragm thickness (Tdi) at end of inspiration and diaphragmatic excursion will be measured on 1st, 3rd, 5th and than every five days during mechanical ventilation by ultrasound in children requiring
Sponsors
Danylo Halytskyy Lviv National Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Presence of informed consent from legal representatives of the child to take part in trial 2. Children aged 1 month - 6 years old 3. Acute respiratory failure with clinical data of excessive work of breathing, laboratory data of hypoxemia, hypercapnia or both, acidosis which leads to need to provide invasive mechanical ventilation
Exclusion criteria
Exclusion criteria: 1. Absence of informed consent from legal representatives of the child to take part in trial at any stage of this trial 2. Acute or chronic respiratory failure without need to provide invasive mechanical ventilation 3. Congenital heart diseases 4. Neuromyotonia according to results of electromyography
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time to liberation from ventilation; every day from baseline the trialists will check the possibility of weaning patients from mechanical ventilation (its mean decreasing of parameters during mechanical ventilation and extubation - both together) and then take into account duration of mechanical ventilation | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Complications (reintubation, tracheostomy, prolonged ventilation, or death); the trialists will check for the presence of these adverse events every day from baseline, then on day 28 of hospitalisation and until patient is discharged from the hospital 2. Electrolyte levels (calcium, potassium, sodium measured using mixed venous blood test on acid-base balance; phosphorus and magnesium measured using biochemical venous blood test) and transthyretin level (blood samples analysed by ELISA); checked on 1st, 3rd, 5th, 7th, 9th and then every five days of mechanical ventilation until patient is weaned from mechanical ventilation and on 3rd and 5th days after weaning | — |
Countries
Ukraine
Contacts
Public ContactOlha Filyk
Outcome results
None listed