Effects of non-invasive brain stimulation on brain activity and brain chemicals in healthy adults

Effects of intermittent theta burst stimulation compared with sham stimulation on magnetic resonance imaging and neurochemical measures in the visual cortex of healthy adults

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN84570603

Enrollment

Registered

2026-05-14

Start date

2016-04-29

Completion date

Unknown

Last updated

2026-05-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy volunteers Other

Interventions

Participants were randomly assigned to either an intermittent theta burst stimulation (iTBS) group or a sham-control group. The order of active and sham stimulation sessions was counterbalanced across

Eligibility

Sex/Gender

All

Age

20 Years to 35 Years

Inclusion criteria

Inclusion criteria: 1. Healthy adults with no history of neurological, medical, visual, or cognitive impairments 2. No contraindications to MRI or TMS, such as a history of seizures or epilepsy, metallic implants, implanted electronic devices (e.g., pacemakers), or pregnancy

Exclusion criteria

Exclusion criteria: 1. A history of neurological, medical, visual, or cognitive impairments 2. Any contraindications to magnetic resonance imaging or transcranial magnetic stimulation, including a history of seizures or epilepsy, metallic implants, implanted electronic devices such as pacemakers, or pregnancy 3. Unable to reliably perceive phosphenes 4. Magnetic resonance imaging or magnetic resonance spectroscopy data did not meet established quality assurance standards

Countries

Taiwan

Contacts

Public ContactLi-Hung Chang

lihung@nycu.edu.tw+886 (0)228267977

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: May 30, 2026