Can we detect early chemotherapy related heart damage in patients with lymphoma using advanced echocardiography?

Detection of early anthracycline induced cardiotoxicity using speckle tracking echocardiography in patients with lymphoma: a retrospective cohort study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN84544539

Enrollment

130

Registered

2018-08-31

Start date

2015-01-01

Completion date

Unknown

Last updated

2020-07-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lymphoma Cancer Haematopoietic cancer

Interventions

This will be a single-centre, retrospective cohort study at the James Cook University Hospital in Middlesbrough. Patients diagnosed with lymphoma between January 2015 to January 2018 will be identifie

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. New diagnosis of histopathologically-confirmed lymphoma between January 2015 and January 2018 2. Received anthracycline based chemotherapy for the treatment of their lymphoma

Exclusion criteria

Exclusion criteria: 1. No adequate echocardiographic imaging on PACS database 2. Explicit dissent and unwillingness to participate in research detailed in the medical notes

Design outcomes

Primary

Measure	Time frame
In addition to describing the medical characteristics of patients with lymphoma in the study, the cardiac function of patients will be measured. This will be assessed by echocardiogram, including: 1. Measurement of left ventricular ejection fraction (LVEF) 2. Measurement of all novel echocardiographic strain parameters on already performed echo scans done prior to chemotherapy, mid-treatment and post chemotherapy: 2.1. Left ventricular global longitudinal strain (GLS) 2.2. Left ventricular global radial strain (GRS) 2.3. Left ventricular global circumferential strain (GCS) 2.4. Torsion and twist 2.5. Right ventricular free wall strain 2.6. Left and right atrial strain 2.7. Strain rates	—

Measure

Time frame

In addition to describing the medical characteristics of patients with lymphoma in the study, the cardiac function of patients will be measured. This will be assessed by echocardiogram, including: 1. Measurement of left ventricular ejection fraction (LVEF) 2. Measurement of all novel echocardiographic strain parameters on already performed echo scans done prior to chemotherapy, mid-treatment and post chemotherapy: 2.1. Left ventricular global longitudinal strain (GLS) 2.2. Left ventricular global radial strain (GRS) 2.3. Left ventricular global circumferential strain (GCS) 2.4. Torsion and twist 2.5. Right ventricular free wall strain 2.6. Left and right atrial strain 2.7. Strain rates

—

Secondary

Measure	Time frame
There are no secondary outcome measures	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026