The actions of phloridzin on sodium ion transporters and potential difference in nasal airway epithelium.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN84503991

Enrollment

Registered

2005-09-30

Start date

2002-10-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory: Chronic obstructive pulmonary disease (COPD) Respiratory Chronic obstructive pulmonary disease (COPD)

Interventions

Nasal potential difference: between the 'sensing' electrode in contact with the nasal epithelium, and the 'reference' electrode, a butterfly needle inserted under the skin of the forearm, is measured.

Eligibility

Inclusion criteria

Inclusion criteria: Healthy, non-smoking volunteers with normal nasal mucosa and random plasma glucose <7mmol/l.

Exclusion criteria

Exclusion criteria: 1. Nasal disease 2. Diabetes mellitus 3. Pregnancy

Design outcomes

Primary

Measure	Time frame
Changes in the measured nasal potential difference with phloridzin	—

Secondary

Measure	Time frame
No secondary outcome measures	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026