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Invitation strategies for colorectal (CRC) screening programmes - The impact of an advance notification letter

Impact of an advance notification letter on participation in CRC screening. Is it different when using sigmoidoscopy or fecal occult blood test (FIT) screening?

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN84448636
Enrollment
60000
Registered
2013-02-19
Start date
2010-10-01
Completion date
Unknown
Last updated
2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal cancer screening Cancer Malignant neoplasm of colon, Malignant neoplasm of rectum

Interventions

1. Standard invitation letter 2. Advance notification letter (mailed 1 month before the personal invitation letter conveying information on CRC risk, screening programme and screening test 3. Advance

Sponsors

ASR Abruzzo (Italy)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: All subjects (male and female) aged 50 to 69 targeted for CRC screening in 8 population based programmes in Italy, using immunochemical fecal occult blood test (FIT) in 5 cases (biennial screening offered to subjects aged 50 to 69), or sigmoidoscopy (FS) in 3 cases (FS offered once in the lifetime to all subjecst aged 58-60)

Exclusion criteria

Exclusion criteria: 1. People with personal or family (>1 first degree relative with CRC) of CRC 2. Inflammatory bowel disease 3. Inability to give an informed consent 4. Severe life-threatening disease

Design outcomes

Primary

MeasureTime frame
Participation rate at 6 months from the invitation letter by study group and screening strategy (FIT and FS)

Secondary

MeasureTime frame
1. Participation rate at 6 months from the invitation stratified by previous screening history (FIT programmes only) 2. Costs of the different options 3. GP's workload and proportion of subjects who accept the offer of a personal encounter

Countries

Italy

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026