SCALE UP: Sustainable model for Cardiovascular health by Adjusting Lifestyle and treatment with Economic perspective in settings of Urban Poverty - Development, implementation and evaluation of a comprehensive intervention package for primary prevention of cardiovascular diseases in the slums of Nairobi

A community-based intervention package for primary prevention of cardiovascular diseases among participants aged 35 years and older in a slum in Nairobi, evaluated in terms of cardiovascular risk outcomes and cost effectiveness, in comparison with the usual standard of care in a similar slum.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN84424579

Enrollment

8390

Registered

2013-04-25

Start date

2012-08-09

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular diseases Circulatory System

Interventions

There is an intervention and control site assigned by convenience.The intervention site was selected because it had a centrally located primary health facility where part of the intervention could be

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: All adults aged 35 years and above living in the slums of Korogocho and Viwandani who give informed consent participate in the study

Exclusion criteria

Exclusion criteria: 1. Pregnant women 2. Persons with undiagnosed CVD such as stroke (including secondary hypertension) 3. All those unable to provide informed consent such as the mentally incapacitated

Design outcomes

Primary

Measure	Time frame
1. The change in the proportion of the study populations (intervention and control slums) that are at moderate or high risk of CVD (defined as >10% risk of developing cardiovascular event in the next five years) 2. The change in mean systolic blood pressure in the study populations (intervention and control slums) 3. The change in mean systolic blood pressure among patients attending the local clinic (intervention slum only) 4. The net cost of the intervention model per disability-adjusted life year gained (intervention slum only)	—

Measure

Time frame

1. The change in the proportion of the study populations (intervention and control slums) that are at moderate or high risk of CVD (defined as >10% risk of developing cardiovascular event in the next five years) 2. The change in mean systolic blood pressure in the study populations (intervention and control slums) 3. The change in mean systolic blood pressure among patients attending the local clinic (intervention slum only) 4. The net cost of the intervention model per disability-adjusted life year gained (intervention slum only)

—

Secondary

Measure	Time frame
1. Prevalence of hypertension in the intervention and control slums 2. Proportion of hypertensive respondents who were aware of their condition in the intervention and control slums 3. Proportion of hypertensive respondents who were aware of their condition and on treatment in the intervention and control slums 4. Proportion of hypertensive respondents who were on treatment and whose blood pressure was under control in the intervention and control slums 5. Proportion of patients attending the local clinic in the intervention slum who blood pressure was under control 6. Proportion of high risk patients who sought first time treatment after screening and referral 7. Prevalence of behavioural CVD risk factors: smoking, physical exercise, diet and alcohol intake in the intervention and control slums	—

Measure

Time frame

1. Prevalence of hypertension in the intervention and control slums 2. Proportion of hypertensive respondents who were aware of their condition in the intervention and control slums 3. Proportion of hypertensive respondents who were aware of their condition and on treatment in the intervention and control slums 4. Proportion of hypertensive respondents who were on treatment and whose blood pressure was under control in the intervention and control slums 5. Proportion of patients attending the local clinic in the intervention slum who blood pressure was under control 6. Proportion of high risk patients who sought first time treatment after screening and referral 7. Prevalence of behavioural CVD risk factors: smoking, physical exercise, diet and alcohol intake in the intervention and control slums

—

Countries

Kenya

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 22, 2026