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A cluster randomised trial of two intensified tuberculosis case-finding strategies in an urban community severely affected by human immunodeficiency virus

A cluster randomised trial of two intensified tuberculosis case-finding strategies in an urban community severely affected by human immunodeficiency virus

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN84352452
Enrollment
120000
Registered
2005-10-14
Start date
2006-02-01
Completion date
Unknown
Last updated
2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tuberculosis Infections and Infestations Tuberculosis

Interventions

Cluster-randomised trial of high density neighbourhoods in Zimbabwe Randomisation unit: each neighbourhood site Number of sites: 46 Each neighbourhood is randomised to receive either mobile clinic o

Sponsors

London School of Hygiene and Tropical Medicine (UK)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Site: 1. Study neighbourhoods based on Census Evaluation Units (CEUs) in residential suburbs of South-West and Western Harare 2. Three to four CEUs combined to provide: a. 2000-3000 adults registered for 2002 Census b. No flats or Halls of Residence c. At least 500 km distance between study neighbourhoods All eligible neighbourhoods included

Exclusion criteria

Exclusion criteria: Individual: 1. Declined consent to participate 2. Aged below 16 years

Design outcomes

Primary

MeasureTime frame
Cumulative yield of TB cases detected through six rounds of periodic (six-monthly) case-finding intervention delivered through either: 1. House-to-house enquiry for chronic coughers 2. Mobile diagnostic clinic visits

Secondary

MeasureTime frame
HIV-specific point prevalence and incidence of active TB disease before and immediately after the intervention (for whole study area with both arms combined) - as of 13/02/2007 this secondary outcome measure was changed to: 'Point prevalence of culture-positive TB disease before and immediately after the intervention (for whole study area with both arms combined)'.

Countries

Zimbabwe

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 30, 2026