Stroke Circulatory System
Conditions
Interventions
1. Transcranial acoustic window with transcranial ultrasound
2. Measuring dynamic cerebral autoregulation
3. Venous blood sample for plasma nitrate
4. Clinical neurological examination
5. Thigh blood
Sponsors
South Devon Healthcare NHS Foundation Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Subjects must have a confirmed onset of acute ischaemic stroke within the last 14 days 2. Age 18-90 3. Able to lie supine and still for 30 minutes 4. Able to take liquid orally 5. Able to give full informed consent 6. Adequate temporal acoustic window as assessed with transcranial doppler ultrasound
Exclusion criteria
Exclusion criteria: 1. Stroke onset within 24 hours 2. Haemorrhagic stroke 3. Pregnant women 4. Dysphagia precluding oral intake of liquid 5. Inadequate temporal acoustic window for transcranial ultrasound 6. Exclude vasoactive drugs including calcium channel blockers 7. Regularly taking organic nitrates, nicorandil, glitazones, phosphodiesterase inhibitors 8. Pre-existing dementia 9. Significant carotid stenosis >70% on carotid doppler 10. Severe peripheral vascular disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Correlation Coefficient (nMx), a marker of dynamic cerebral autoregulation, at 2 hours following ingestion of the investigational product | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Plasma nitrate level 2. Mean arterial blood pressure 3. Standard cerebral haemodynamics 4. National Institutes of Health Stroke Scale (NIHSS) 5. Modified Rankin Score (mRS) Measured at 2 hours following ingestion of the investigational product. | — |
Countries
United Kingdom
Outcome results
None listed