Transfusion and treatment of severe anaemia in African children trial

Conditions

Severe anaemia Haematological Disorders Nutritional anaemias

Peter Olupot‐Olupot, Roisin Connon, Sarah Kiguli, Robert O. Opoka, Florence Alaroker et al. (23 authors)

American Journal of Hematology2022-02-117 citations

Incidence and predictors of hospital readmission in children presenting with severe anaemia in Uganda and Malawi: a secondary analysis of TRACT trial data.

Connon R, George EC, Olupot-Olupot P, Kiguli S, Chagaluka G, Alaroker F, Opoka RO, Mpoya A, Walsh K, Engoru C, Nteziyaremye J, Mallewa M, Kennedy N, Nakuya M, Namayanja C, Nabawanuka E, Sennyondo T, Amorut D, Williams Musika C, Bates I, Boele van Hensbroek M, Evans JA, Uyoga S, Williams TN, Frost G, Gibb DM, Maitland K, Walker AS, TRACT trial group.

2021-07-2912 citations

10.1186/s12889-021-11481-6

Co-trimoxazole or multivitamin multimineral supplement for post-discharge outcomes after severe anaemia in African children: a randomised controlled trial.

Maitland K, Olupot-Olupot P, Kiguli S, Chagaluka G, Alaroker F, Opoka RO, Mpoya A, Walsh K, Engoru C, Nteziyaremye J, Mallewa M, Kennedy N, Nakuya M, Namayanja C, Kayaga J, Nabawanuka E, Sennyondo T, Aromut D, Kumwenda F, Musika CW, Thomason MJ, Bates I, von Hensbroek MB, Evans JA, Uyoga S, Williams TN, Frost G, George EC, Gibb DM, Walker AS, TRACT trial group.

2019-10-0126 citations

10.1016/s2214-109x(19)30345-6

Immediate Transfusion in African Children with Uncomplicated Severe Anemia

Kathryn Maitland, Sarah Kiguli, Peter Olupot‐Olupot, Charles Engoru, Macpherson Mallewa et al. (26 authors)

New England Journal of Medicine2019-07-3186 citations

10.1056/nejmoa1900105

Transfusion Volume for Children with Severe Anemia in Africa

Kathryn Maitland, Peter Olupot‐Olupot, Sarah Kiguli, George Chagaluka, Florence Alaroker et al. (26 authors)

New England Journal of Medicine2019-07-3164 citations

10.1056/nejmoa1900100

Validation of triple pass 24-hour dietary recall in Ugandan children by simultaneous weighed food assessment

H. W. Nightingale, Kevin Walsh, Peter Olupot‐Olupot, Charles Engoru, Tonny Ssenyondo et al. (11 authors)

BMC Nutrition2016-08-2431 citations

10.1186/s40795-016-0092-4

Transfusion and Treatment of severe anaemia in African children (TRACT): a study protocol for a randomised controlled trial.

Mpoya A, Kiguli S, Olupot-Olupot P, Opoka RO, Engoru C, Mallewa M, Chimalizeni Y, Kennedy N, Kyeyune D, Wabwire B, M'baya B, Bates I, Urban B, von Hensbroek MB, Heyderman R, Thomason MJ, Uyoga S, Williams TN, Gibb DM, George EC, Walker AS, Maitland K.

2015-12-2938 citations

10.1186/s13063-015-1112-4

Interventions

The trial will have a factorial design with 3 randomisations, each to address one of the potential approaches to reducing mortality and morbidity in children with SA: R1: Immediate li

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Children will be recruited at the point of hospital admission 1. Aged 2 months to 12 years 2. Severe anaemia (SA) (Hb<6g/dl) within 2h of admission to hospital 3. Carer willing/able to provide consent

Exclusion criteria

Exclusion criteria: 1. Malignancy 2. Surgery 3. Acute trauma 4. Signs of bi-ventricular heart failure

Design outcomes

Secondary

Measure	Time frame
1. Mortality at 48 hours, 28 days, 90 day and 180 days (cumulative) (where not the primary outcome). 2. Morbidity: endpoints relating to the specific mechanisms of action of each intervention: 2.1. Re-admission to hospital 2.2. Proportion achieving correction of anaemia (defined by WHO as Hb>9g/dl) at 48 hours, 28 days, 90 day and 180 days 2.3. Development of new profound anaemia (Hb<4g/dl) during acute admission or development of severe anaemia (Hb<6g/dl) post discharge 3. Nutrition: changes in weight and MUAC at 90 day and 180 days 4. Anti-infection: changes in inflammatory markers (CRP, PCT), incidence of bacterial infections and malaria at 28 days, 90 day and 180 days	—

Measure

Time frame

1. Mortality at 48 hours, 28 days, 90 day and 180 days (cumulative) (where not the primary outcome). 2. Morbidity: endpoints relating to the specific mechanisms of action of each intervention: 2.1. Re-admission to hospital 2.2. Proportion achieving correction of anaemia (defined by WHO as Hb>9g/dl) at 48 hours, 28 days, 90 day and 180 days 2.3. Development of new profound anaemia (Hb<4g/dl) during acute admission or development of severe anaemia (Hb<6g/dl) post discharge 3. Nutrition: changes in weight and MUAC at 90 day and 180 days 4. Anti-infection: changes in inflammatory markers (CRP, PCT), incidence of bacterial infections and malaria at 28 days, 90 day and 180 days

—

Primary

Measure	Time frame
Cumulative mortality to 4 weeks for the transfusion strategy comparison, and to 6 months for the nutritional support/antibiotic prophylaxis comparison	—

Countries

Malawi, Uganda

Outcome results

None listed