Antibiotics to prevent preterm birth

Conditions

Preterm birth Pregnancy and Childbirth Preterm birth

van den Broek NR, Jean-Baptiste R, Neilson JP.

2014-03-0361 citations

10.1371/journal.pone.0090128

Post-neonatal mortality, morbidity, and developmental outcome after ultrasound-dated preterm birth in rural Malawi: a community-based cohort study.

Gladstone M, White S, Kafulafula G, Neilson JP, van den Broek N.

2011-11-0840 citations

10.1371/journal.pmed.1001121

The APPLe study: a randomized, community-based, placebo-controlled trial of azithromycin for the prevention of preterm birth, with meta-analysis.

van den Broek NR, White SA, Goodall M, Ntonya C, Kayira E, Kafulafula G, Neilson JP.

2009-12-0168 citations

10.1371/journal.pmed.1000191

Interventions

Azithromycin 1 g orally or placebo at 16 - 24 weeks and 28 - 32 weeks. For main trial, follow-up was to 6 weeks after birth. Children have been followed up to 18 months of age.

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Pregnant women less than 24 weeks gestational age by ultrasound at recruitment 2. No age restriction, apart from age being compatible with pregnancy 3. Intention to remain within the district throughout pregnancy 4. Informed consent

Exclusion criteria

Exclusion criteria: Does not meet inclusion criteria

Design outcomes

Primary

Measure	Time frame
Preterm birth (less than 37 weeks gestation).	—

Secondary

Measure	Time frame
1. Mean gestational age at birth 2. Perinatal mortality 3. Birthweight 4. Malarial parasites at 28 - 32 weeks 5. Haemoglobin at 28 - 32 weeks	—

Countries

Malawi

Outcome results

None listed