Correlating the cough as a result of fentanyl injection while instituting general anaesthesia with the occurrence of nausea and vomiting after surgery in female patients

Correlation between fentanyl-induced cough (FIC) and postoperative nausea and vomiting (PONV) in female patients under general anaesthesia

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN83969715

Enrollment

263

Registered

2023-02-07

Start date

2019-11-01

Completion date

Unknown

Last updated

2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fentanyl-induced cough during general anaesthesia and postoperative nausea and vomiting in female patients Surgery

Interventions

Data is collected from adult female patients who come for elective surgeries under general anaesthesia from Sept 2019 - Sept 2021. All patients are nil per oral, 6 hours for solids and 2 hours for cle

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Female patients aged 18-59 years 2. American Society of Anaesthesiologists (ASA) physical status 1 and 2 3. Surgery lasting for 1- 3 hours duration under general anaesthesia

Exclusion criteria

Exclusion criteria: 1. History of bronchial asthma or chronic obstructive pulmonary disease 2. Smoking status 3. Respiratory or gastrointestinal infection in the previous 2 weeks 4. Preoperative use of an angiotensin-converting enzyme inhibitor, an antiemetic, a bronchodilator or a steroid 5. History of PONV or motion sickness 6. Laparoscopic surgeries 7. Surgeries for malignant lesions

Design outcomes

Primary

Measure	Time frame
1. Fentanyl-induced cough is defined as the occurrence of any episode of cough within 60 seconds of intravenous fentanyl administration 2. Postoperative nausea and vomiting (PONV) is defined as any degree of nausea or vomiting within the first 24 hours after surgery, recorded on a score of 0, 1, or 2 (0 = no nausea or vomiting, 1 = tolerable nausea or vomiting, and 2 = intractable nausea or vomiting requiring medication)	—

Measure

Time frame

1. Fentanyl-induced cough is defined as the occurrence of any episode of cough within 60 seconds of intravenous fentanyl administration 2. Postoperative nausea and vomiting (PONV) is defined as any degree of nausea or vomiting within the first 24 hours after surgery, recorded on a score of 0, 1, or 2 (0 = no nausea or vomiting, 1 = tolerable nausea or vomiting, and 2 = intractable nausea or vomiting requiring medication)

—

Secondary

Measure	Time frame
There are no secondary outcome measures	—

Countries

India

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026