Can a new talking therapy for people with bipolar disorders lead to improvements that are better than their usual treatment?

A pilot randomised controlled trial of CBT for people with bipolar disorders and current symptoms: Think Effectively About Mood Swings (TEAMS)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN83928726

Enrollment

Registered

2014-07-25

Start date

2011-10-21

Completion date

Unknown

Last updated

2018-11-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Topic: Mental Health

Interventions

TEAMS, Think Effectively About Mood Swings - a novel cognitive therapy based on an integrative cognitive model (Mansell et al., 2007).

Follow Up Length: 18 month(s)

Study Entry : Single Randomisation only

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Meet DSM-IV criteria for bipolar I or II disorder, or bipolar disorder not otherwise specified, characterised by a past major depressive episode and DSM-IV hypomania of two days or more (Akiskal et al., 2006). 2. Complete baseline assessment sessions in an outpatient setting 3. A baseline score of at least 15 on the Beck Depression Inventory that is maintained over two consecutive weeks prior to the study (to ensure presence of significant current distress as targeted in the trial) 4. Aged 16 and above

Exclusion criteria

Exclusion criteria: 1. A diagnosis of a non-affective psychotic disorder according to DSM-IV 2. Current mania or mixed episode according to DSM-IV 3. A primary substance use disorder according to DSM-IV 4. Moderate to severe learning disability 5. Organic impairment that accounts for mental health problem 6. Non-English speaking (owing to the standardised assessment measures)

Design outcomes

Primary

Measure	Time frame
Beck Depression Inventory (Beck et al., 1961); Timepoint(s): self-report scale administered at baseline, and 3, 6, 12, and 18 months post randomization.	—

Secondary

Measure	Time frame
1. Anxiety (GAD-7; Spitzer et al., 2006); Timepoint(s): 0, 3, 6, 12, 18 months 2. Composite internal state scale score (ISS; Bauer et al., 1991); Timepoint(s): 0, 3, 6, 12, 18 months 3. Hamilton (1960) Depression; Timepoint(s): 0, 3, 6, 9, 12, 18 months 4. Health status (EQ-5D/Euroqol, Kind et al 1996).; Timepoint(s): 0, 3, 6, 12, 18 months 5. Hypomanic Attitudes and Positive Predictions Inventory; Dodd et al., 2009; Mansell, 2006; Timepoint(s): 0, 3, 6, 12, 18 months 6. Measure of manic symptoms (Bech-Rafaelson; Bech et al., 1978); Timepoint(s): 0, 3, 6, 12, 18 7. Recovery measure (Pitt et al., in press); Timepoint(s): 0, 3, 6, 12, 18 months 8. SCID-LIFE interview for episodes of mania or depression (Paykel et al., 2006); Timepoint(s): 0, 3, 6, 12, 18 months	—

Measure

Time frame

1. Anxiety (GAD-7; Spitzer et al., 2006); Timepoint(s): 0, 3, 6, 12, 18 months 2. Composite internal state scale score (ISS; Bauer et al., 1991); Timepoint(s): 0, 3, 6, 12, 18 months 3. Hamilton (1960) Depression; Timepoint(s): 0, 3, 6, 9, 12, 18 months 4. Health status (EQ-5D/Euroqol, Kind et al 1996).; Timepoint(s): 0, 3, 6, 12, 18 months 5. Hypomanic Attitudes and Positive Predictions Inventory; Dodd et al., 2009; Mansell, 2006; Timepoint(s): 0, 3, 6, 12, 18 months 6. Measure of manic symptoms (Bech-Rafaelson; Bech et al., 1978); Timepoint(s): 0, 3, 6, 12, 18 7. Recovery measure (Pitt et al., in press); Timepoint(s): 0, 3, 6, 12, 18 months 8. SCID-LIFE interview for episodes of mania or depression (Paykel et al., 2006); Timepoint(s): 0, 3, 6, 12, 18 months

—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 19, 2026