Evaluation of a urinary test to assess vitamin B12 status in older people

Urinary MethylMalonic Acid (MMA): a functional biomarker of B12 status applicable to large scale surveys: Part 1 - the cross sectional study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN83921062

Enrollment

600

Registered

2011-11-28

Start date

2008-01-01

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Public health/nutrition particularly in older people

Interventions

Men and women aged 65 to 85, with no clinical evidence of vitamin B12 deficiency, will be recruited from GP practices in the Sheffield area. They will be asked to supply a small blood sample for the m

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Men and women (aged 65 to 85) 2. Healthy

Exclusion criteria

Exclusion criteria: 1. Severe cognitive impairment 2. Gastric or ileal surgery 3. Regular vitamin B12 injections

Design outcomes

Primary

Measure	Time frame
Urinary methylmalonic acid corrected for urinary creatinine	—

Secondary

Measure	Time frame
1. Serum holotranscobalamin 2. Plasma vitamin B12 3. Plasma pepsinogen I 4. Full Blood Count 5. Plasma cystatin 6. Dietary assessment 7. Lifestyle questionnaire	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026