Ischaemic stroke Circulatory System Stroke
Conditions
Interventions
Combined aspirin (75 mg once a day [od], A), dipyridamole (200 mg twice a day [bd], B) and clopidogrel (75 mg od, C) versus aspirin (75 mg od, A) alone.
Sponsors
University of Nottingham (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18 years or older 2. Ischaemic stroke on computed tomography (CT)/magnetic resonance imaging (MRI) within 5 years 3. Previous transient ischemic attack (TIA) within 5 years 4. Written informed consent from patient 5. In sinus ryhthm or atrial fibrillation but not suitable for anticoagulation
Exclusion criteria
Exclusion criteria: 1. Thrombocytopenia 2. Severe hypertension 3. Previous cerebral haemorrhage 4. Hypersensitivity or intolerance to aspirin, dipyridamole or clopidogrel 5. Any history of peptic ulcer or gastrointestinal bleeding 6. Severe concomitant medical conditions including acquired immunodeficiency syndrome (AIDS) or cancer 7. Pregnancy or breast feeding 8. Patients needing or already receiving anticoagulant or non-steroidal anti-inflammatory drugs (NSAIDs) other than aspirin therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of subjects completing randomised treatment to final follow up. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Recurrent ischaemic stroke or TIA 2. Intracerebral haemorrhage 3. Major extracranial bleeding 4. Minor extracranial bleeding (epistaxis, purpura) 5. Sitting and standing blood pressure (BP), heart rate at 2 weeks, 3 months and follow up 6. Presence of headache | — |
Countries
United Kingdom
Outcome results
None listed