Testing whether ketamine and magnesium sulfate can reduce pain after kidney removal surgery

Sequence-dependent analgesic efficacy of perioperative intravenous ketamine and magnesium sulfate in patients undergoing open radical nephrectomy: a randomized, double-blind, placebo-controlled clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN83633282

Enrollment

208

Registered

2026-03-14

Start date

2017-08-01

Completion date

Unknown

Last updated

2026-05-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pain, renal cell carcinoma, radical nephrectomy, multimodal analgesia Cancer

Interventions

Patients were randomized into one of nine subgroups defined by two sequential intravenous bolus injections (Drug A administered immediately after induction of anesthesia, Drug B administered 10 minute

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Age =18 years 2. ASA physical status class I–III 3. Unilateral renal tumor scheduled for elective open radical nephrectomy

Exclusion criteria

Exclusion criteria: 1. Resting bradycardia or AV block 2. NYHA functional class greater than 2 3. GFR less than 50 ml/min 4. Severe COPD or asthma 5. Poorly controlled arterial hypertension 6. Severe hepatic impairment 7. Elevated IOP or ICP 8. Significant psychiatric comorbidity 9. Known allergy to study medications 10. Pre-existing chronic pain syndrome 11. Regular analgesic use in the month preceding surgery

Countries

Serbia

Contacts

Public ContactNebojsa;Zoran Ladjevic;Dzamic

;

nebojsa.ladjevic@med.bg.ac.rs;dzamiczoran960@gmail.com+38111 3636300;+38111 3636300

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: May 22, 2026