Neonatal Diseases: Respiratory Neonatal Diseases Respiratory
Conditions
Interventions
Babies up to 30 week gestation and requiring ventilatory support would be eligible for study pre-extubation. Signed informed parental consent will be sought before randomisation.Babies will be random
Sponsors
Record Provided by the NHSTCT Register - 2006 Update - Department of Health
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Born between 24 and less than 30 weeks gestation, or with a birth weight of 600 to 1500 grams 2. Endotracheal intubation for any duration 3. Stable or improving respiratory status with inspired oxygen concentration of less than 50% 4. First extubation attempt 5. Signed parental consent 6. Considered ready for extubation by the clinical management team
Exclusion criteria
Exclusion criteria: 1. Major congenital malformations, which are known to adversely affect life expectancy 2. Known congenital or acquired upper airway obstruction 3. Neuromuscular disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Respiratory failure within 72 hours defined as: 1. Need for re-intubation primarily for respiratory distress AND/OR 2. Uncompensated Respiratory Acidosis (pH8kPa | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Endotracheal reintubation 2. Duration of CPAP days 3. Chronic Lung Disease, Morbidity, Mortality and Data on complications including gastrointestinal will be collected. | — |
Countries
United Kingdom
Outcome results
None listed