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A practice level intervention to reduce antibiotic prescribing for self-limiting infections in primary care

Impact of a mixed patient and GP intervention level intervention on antibiotic prescribing in GP practices in England: A cluster randomised controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN83322985
Enrollment
175
Registered
2015-09-30
Start date
2015-10-01
Completion date
Unknown
Last updated
2020-08-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Antimicrobial resistance Infections and Infestations Antimicrobial resistance

Interventions

Randomisation of GP practices will be stratified by Clinical Commissioning Group (CCG) using an even-split-within-strata method, which ensures numerical balance within each CCG. Regression analysis wi

Sponsors

Public Health England
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. All or the vast majority of GPs, practice nurses and non-medical prescribers are willing to take part in the study which may involve emailing a photograph and electronic signature 2. Can display the personalised posters in the GP consulting rooms 3. Can implement or amend an existing automated call-waiting message to record and play the AMR message (ideally first or last) and leave in place for the duration of the study

Exclusion criteria

Exclusion criteria: 1. Walk-in centres 2. More than 20% of our appointments bookings are made online 3. Those which already display AMR GP commitment posters or play AMR call waiting messages (other AMR related activity and posters are fine, including antibiotic guardian posters)

Design outcomes

Primary

MeasureTime frame
EPACT data (STARPU adjusted) on filled antibiotic prescriptions per 1000 of the population for a baseline period of 3 months and the 4 month intervention period, and for the same intervention period the previous year.

Secondary

MeasureTime frame
Percentage of all filled antibiotic prescriptions that are for broad-spectrum antibiotics. Measured at baseline for a period of 3 months and the 4 month intervention period and for the same intervention period the previous year.

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026