Microvascular monitoring during liver resection surgery - a pilot study

Microvascular monitoring during liver resection surgery - a pilot prospective observational cohort study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN83180572

Enrollment

Registered

2015-03-20

Start date

2014-12-01

Completion date

Unknown

Last updated

2017-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver surgery, microcirculatory monitoring Surgery

Interventions

Patients enrolled into the study will have imaging of the blood flow in the small blood vessels in their tongue. This will be measured by placing a camera underneath the tongue, similar to positioning

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. At least 18 years of age 2. Elective (planned) liver resection surgery 3. Provides informed consent to participate in surgery

Exclusion criteria

Exclusion criteria: 1. Glossectomy (previous surgery to remove part or all of the tongue) 2. Glossitis (inflammation of the tongue) 3. Lack of mental capacity

Design outcomes

Primary

Measure	Time frame
The primary analysis will compare the proportion of perfused vessels (PPV, %) for small (<20 µm) vessels at two time points: A (pre-anaesthetic); and during the liver resection surgery when the patient is maximally 'dessicated' (time B) using paired T-test or Wilcoxon non-parametric method if assumptions of normality are not met. Two-sided (5%) alpha level will be used to assess significant difference.	—

Measure

Time frame

The primary analysis will compare the proportion of perfused vessels (PPV, %) for small (<20 µm) vessels at two time points: A (pre-anaesthetic); and during the liver resection surgery when the patient is maximally 'dessicated' (time B) using paired T-test or Wilcoxon non-parametric method if assumptions of normality are not met. Two-sided (5%) alpha level will be used to assess significant difference.

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Secondary

Measure	Time frame
1. Another analysis will compare the paired PPV at times A and C (pre-anaesthetic and after GDFT, respectively) using the same paired T-test or Wilcoxon non-parametric method 2. The patients' PPV at all time (A, B and C) points will be compared between groups (with and without complications; with less than, or greater than, the median peak lactate in the first 24 hours; does/does not require vasoactive therapy for greater than 24 hours on ICU) using two-way repeated measures ANOVA for each variable separately or appropriate non-parametric method. Post hoc test will use Bonferroni method to adjust for multiple testing 3. To assess the relationship between automated Microscan measurements from sublingual and hepatic measurements taken during the intra-operative period Pearson's correlation coefficient or Spearman's rank correlation will be used as appropriate	—

Measure

Time frame

1. Another analysis will compare the paired PPV at times A and C (pre-anaesthetic and after GDFT, respectively) using the same paired T-test or Wilcoxon non-parametric method 2. The patients' PPV at all time (A, B and C) points will be compared between groups (with and without complications; with less than, or greater than, the median peak lactate in the first 24 hours; does/does not require vasoactive therapy for greater than 24 hours on ICU) using two-way repeated measures ANOVA for each variable separately or appropriate non-parametric method. Post hoc test will use Bonferroni method to adjust for multiple testing 3. To assess the relationship between automated Microscan measurements from sublingual and hepatic measurements taken during the intra-operative period Pearson's correlation coefficient or Spearman's rank correlation will be used as appropriate

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Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026