Pain Signs and Symptoms Pain
Conditions
Interventions
The ten volunteers each attended five three-hour laboratory sessions on separate occasions. In each session, the volunteer received one of the following treatments:
Placebo (saline)
Propofol
Ketamine
Sponsors
Monash Medical Centre (Australia)
Eligibility
Inclusion criteria
Inclusion criteria: Ten healthy male volunteers were recruited via bulletin board advertisements. The volunteers were trained in the test procedures employed and medically screened.
Exclusion criteria
Exclusion criteria: Volunteers were excluded if they had a history of cardiac, neurological, or musculoskeletal disease. Other exclusion criteria included a history of drug abuse, pain syndromes, myasthenia gravis, acute narrow angle glaucoma, asthma, or heart failure, concurrent use of any analgesics, sedatives, erythromycin, monoamine oxidase (MAO) inhibitors, or allergy to propofol, fentanyl, or ketamine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain threshold to electrical current, pain threshold to contact heat, pain threshold to pressure, visual analogue scale for sedation, Observer Assessment of Alertness/Sedation Scale (OASS), Symbol Digit Modalities Test (SDMT), auditory reaction time | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
Australia
Outcome results
None listed