Interaction between herbal remedies (danshen and baizhi) and caffeine

Caffeine/Angelica dahurica and caffeine/Salvia miltiorrhiza metabolic inhibition in humans: In vitro and in vivo studies.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN83028296

Enrollment

Registered

2019-06-11

Start date

2012-06-20

Completion date

Unknown

Last updated

2023-08-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

N/A Not Applicable

Interventions

Participants are asked to refrain from ingesting caffeine, caffeinated drinks and furanocoumarin-containing foods for 3 days before and after participating in the first pharmacokinetic study (without

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Aged 20-35 years

Exclusion criteria

Exclusion criteria: 1. Smoker 2. On medication 3. Pregnant or breast feeding 3. Any health issue(s) that would affect the results of the study

Design outcomes

Primary

Measure	Time frame
Caffeine concentrations in human saliva collected at 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 7, 8 and 12 hr post-dosing using liquid chromatography	—

Secondary

Measure	Time frame
Caffeine concentrations in urine collected 4 - 8 hours post-dosing	—

Countries

Canada

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026