Chronic obstructive pulmonary disease (COPD) Respiratory Other chronic obstructive pulmonary disease
Conditions
Interventions
COPD accounts for 25,000 - 30,000 deaths every year in the UK. COPD prevalence is difficult to estimate because of variable definitions and underdiagnosis. The National Institute of Clinical Excellenc
Sponsors
Hywel Dda Health Board (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients (aged 40 - 90 years, either sex) with a diagnosis of COPD, according to Global initiative for chronic Obstructive Lung Disease (GOLD) 2. Healthy controls with no symptoms of COPD and no evidence of airflow obstruction on spirometry
Exclusion criteria
Exclusion criteria: 1. Patients unable or unwilling to give informed consent 2. Those with a current or previous diagnosis of cancer 3. Those with known co-existent asthma, bronchiectasis or pulmonary fibrosis, severe heart failure (ejection fraction [EF] less than 35% on echocardiogram or chronic renal failure - estimated glomerular filtration rate [eGFR] less than 60/ml/min/1.73 m^2) 4. Currently suffering an exacerbation (at enrolment)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To develop receiver operator curves for sputum FTIR, sputum extensional rheology and exhaled VOCs in differentiating COPD patients from non-COPD controls. Measured over 2 years. | — |
Secondary
| Measure | Time frame |
|---|---|
| Measured over 2 years: 1. To correlate changes in sputum FTIR, rheology and exhaled VOCs with severity of airflow obstruction in COPD 2. To compare profiles of sputum FTIR, rheology and exhaled VOCs in stable COPD and during an exacerbation | — |
Countries
United Kingdom
Outcome results
None listed