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Combined treatment of patients with stroke-type neurosyphilis

Efficacy of hyperbaric oxygen therapy combined with ultrasound–neuromuscular electrical stimulation and traditional Chinese medicine acupuncture in patients with stroke-type neurosyphilis

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN82897356
Enrollment
190
Registered
2026-07-02
Start date
2022-03-01
Completion date
Unknown
Last updated
2026-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke-type neurosyphilis Infections and Infestations

Interventions

Patients were randomised 1:1 into the experimental group or the control group using a computer-generated random number table. Control arm (standard care): Participants receive standard neurosyphilis

Sponsors

The Fifth People’s Hospital of Suzhou
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Positive serum and cerebrospinal fluid (CSF) Treponema pallidum particle agglutination 2. CSF white blood cell count >5/µL or elevated protein (>0.45 g/L) 3. Imaging-confirmed cerebral infarction (computed tomography [CT] or magnetic resonance imaging [MRI]) 4. Clinical presentation consistent with acute stroke (hemiparesis, aphasia, etc). All participants had neurological deficits with a National Institutes of Health Stroke Scale (NIHSS) score =5.

Exclusion criteria

Exclusion criteria: 1. Comorbid major neurological disorders 2. Contraindications to HBO therapy, TUS-NMES or acupuncture 3. Pregnancy or breastfeeding 4. Inability to comply with rehabilitation

Design outcomes

Primary

MeasureTime frame
Neurological recovery measured using the National Institutes of Health Stroke Scale (NIHSS) at 28 days;Functional independence measured using the Barthel Index of Activities of Daily Living at 28 days

Countries

China

Contacts

Public ContactMinzhi Wu
wuminzhi1202025021@126.com+86 (0)15150187616

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Jul 23, 2026