Depression Mental and Behavioural Disorders Depressive episode
Conditions
Interventions
Cognitive behaviour therapy versus metacognitive behaviour therapy.
The two therapists in the trial give both treatment. Patients are referred according to therapist availability. The
Sponsors
University of Manchester (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients (male and female, aged 18-68 years) who have a main or primary diagnosis of major depressive disorder (MDD) according to Structured Clinical Interview for DSM-IV Disorders (SCID) I. 2. Patients who only attend therapy in this trial and have not received other psychological treatments for the current episode. 3. Patients in combined medical treatment as long as they are stable or willing to remain stable on their medication for the period of the trial. 4. Patients who sign informed consent
Exclusion criteria
Exclusion criteria: 1. Patients suffering from psychosis or bipolar disorder as screened by SCID I 2. Patients suffering from substance and alcohol-abuse as screened by SCID I 3. Patients suffering from borderline personality disorder as screened by SCID II 4. Patients with organic brain syndrome or mental retardation 5. Female patients who are pregnant or lactating 6. Participants who had not responded favorably to an earlier adequate trial of either CBT or MCT
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Depressive symptoms (Hamilton Depression Inventory administered by blind assessor) 2. Depressive symptoms on self report questionnaire (Beck Depression Inventory ? BDI-II Measured before, mid, post and at 6 months follow-up. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Anxiety related symptoms (Beck Anxiety Inventory - BAI) 2. Co-morbidity (SCID I) 3. Patients? expectancies about treatment outcome 4. Meta-cognitive scales (Meta-cognitive Questionnaire - MCQ-30, negative and positive beliefs about rumination scales (NBRS PBRS), Rumination Response Scale (RRS) 5. CBT specific scales (Dysfunctional Attitude Scale DAS and Young?s Schema Inventory - short version) 6. Patient-therapist alliance (Havarth Aliance Inventory HAI) 7. Objective measure (Concentration and attention subtests from the WAIS) Measured before, mid, post and at 6 months follow-up. | — |
Countries
Denmark
Outcome results
None listed