Comparison of traditional and fluorescence detection of non-melanoma skin cancer

Observer blinded intra-patient direct comparison of the accuracy of classical method and auto-fluorescence normalized liposomal encapsulated 5-aminolevulinic acid induced protoporphyrin IX (PpIX) fluorescence detection method of detecting non-melanoma skin cancer

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN82324581

Enrollment

Registered

2011-11-07

Start date

2011-11-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-melanoma skin cancer Cancer Malignant neoplasm of skin, unspecified

Interventions

Visual inspection and palpation for the detection of non-melanoma skin cancer versus auto-fluorescence normalized liposomal encapsulated 5-aminolevulinic induced protoporphyrin IX fluorescence detecti

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Male and female aged 40 and over 2. History of NMSC 3. Being referred to a dermatologist for a NMSC check-up

Exclusion criteria

Exclusion criteria: 1. Use of a peeling agent 2. Use of 5-fluorouracil (5-FU) 3. Skin type IV or higher 4. Skin type III with tanning less than two months prior to the participation 5. Recent tanning 6. Porphyria 7. Epilepsy 8. Inflammatory disease (e.g. psoriasis, acne) 9. Excessive hair on chest or face

Design outcomes

Primary

Measure	Time frame
1. False positives, false negatives, true positives and true negatives are recorded for both methods 2. The true and false negatives are calculated using the combined locations of true and false positives of both methods. Based on these sensitivity and specificity of both methods are calculated.	—

Secondary

Measure	Time frame
No secondary outcome measures	—

Countries

Netherlands

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026