Renal failure Urological and Genital Diseases Unspecified renal failure
Conditions
Interventions
Subjects will have a measure of their forearm blood flow made on three occasions:
1. Immediately before the insertion of the regional block for surgery
2. Immediately after the insertion of the regio
Sponsors
Nottingham University Hospitals NHS Trust (UK)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Patients with end stage renal failure 2. Over 18 years of age, either sex 3. Written consent obtained 4. Due to undergo surgery for forearm fistula creation under a regional block
Exclusion criteria
Exclusion criteria: 1. Smokers 2. Damaged skin on the arm 3. Circulatory disorders such as Raynaud's disease, systemic sclerosis, sickle cell trait or disease 4. Current use of beta blockers 5. Undergoing haemodialysis for more than 12 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. The transient hyperaemic response ratio (THRR) will be calculated for each compression using the formula THRR = F2/F1 where F1 is the initial fall in blood flow flux following compression of the brachial artery and F2 is the hyperaemic response following its release. The mean of each set of readings will be taken and compared with the subjects' normal values using a paired t-test. 2. Skin temperature will be compared before and after the regional block and dialysis using a t-test Measured at pre-regional block, immediately post-regional block onset, and 4 hours after regional block. | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary outcome measures | — |
Countries
United Kingdom
Outcome results
None listed