Hookworm infection (Necator americanus and Ancylostoma duodenale) Infections and Infestations Hookworm infection
Conditions
Interventions
Intervention group: single oral dose of 400 mg tribendimidine
Control group: single oral dose of 400 mg albendazole
Sponsors
Swiss Tropical Institute (Switzerland)
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Hookworm egg positive adult males (16-45 years) recruited at community survey in the region of Agboville (south Ivory Coast ) with written informed consent
Exclusion criteria
Exclusion criteria: 1. Any abnormal medical condition judged by the investigating medical team 2. Hypersensitivity to albendazole or any other anthelmintic drug 3. Taken any anthelmintic drug during the last month before enrolment 4. Hookworm egg negative after 4 Kato-Katz thick smears done on two consecutive stool specimens
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Cure rate at 21 day post-administration 2. Egg reduction rate at 21 day post-administration 3. Observed acute adverse events within 1-3 hours and solicited adverse events within 24 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| Rate of perceived illness episodes throughout the 6 months follow-up period with 1 week recall period | — |
Countries
Cote d'Ivoire
Outcome results
None listed