Non small cell lung cancer Cancer Non small cell lung cancer
Conditions
Interventions
Modafinil 100 mg daily for one week, increasing to 200 mg daily for one week
Sponsors
Cambridge University Hospitals NHS Foundation Trust (UK)
Eligibility
Inclusion criteria
Inclusion criteria: 1. Histologically or cytologically confirmed non-small cell lung cancer (NSCLC) 2. A fatigue score of four using bimodal scoring in the Chalder fatigue scale 3. World Health Organisation (WHO) performance status of 0-3 4. Ability to give informed consent to participate
Exclusion criteria
Exclusion criteria: 1. Received radiotherapy or chemotherapy within the last four weeks 2. Commenced on antidepressants or steroids (corticosteroids and progestational steroids) within the last two weeks 3. Received blood transfusion within the last two weeks 4. Potentially fertile women of child-bearing age 5. Uncontrolled moderate to severe hypertension, arrhythmia 6. Previous adverse reaction to modafinil or other central nervous system (CNS) stimulant 7. Current active involvement in another clinical trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in fatigue | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in sleepiness and depression levels | — |
Countries
England, United Kingdom
Outcome results
None listed