Adiposity in pregnancy Pregnancy and Childbirth
Conditions
Interventions
All pregnant women who book their antenatal care with the Newcastle upon Tyne Hospitals NHS Foundation Trust (NUTH) are sent a research information letter outlining that NUTH is a research active Trus
Sponsors
Newcastle upon Tyne Hospitals NHS Foundation Trust
Eligibility
Sex/Gender
Female
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Singleton pregnancy (women who consent to participate but who are subsequently found to have a multiple pregnancy will be excluded) 2. =18 years of age 3. Approximately 12 weeks’ gestation (11+2 to 14+1 weeks) 4. Planned delivery at NUTH
Exclusion criteria
Exclusion criteria: 1. Unable/unwilling to give informed consent to participate 2. Women with a miscarriage prior to the 12-week scan, or threatened miscarriage identified on the patient's records as a visit to the Early Pregnancy Assessment Clinic (EPAC) or A&E relating to their pregnancy with an adverse outcome, will be excluded 3. Women having twins (or higher order pregnancy) - we will not know whether women have a multiple pregnancy until their 12-week scan appointment (after consent). Any women identified as having a multiple pregnancy at the 12-week scan will be excluded
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All outcomes are collected from routine maternity records following birth: 1. Gestational diabetes: fasting plasma glucose level of = 5.6 mmol/litre or 2-hour plasma glucose level of =7.8 mmol/litre 2. Preeclampsia (PE): new onset of hypertension (>140 mmHg systolic or >90 mmHg diastolic) after 20 weeks of pregnancy with a new onset of proteinuria or/and maternal organ dysfunction or/and uteroplacental dysfunction. Early onset defined as onset of PE before 34 weeks gestation. 3. Pre-term birth: birth before 37 weeks gestation 4. Small for gestational age: birth weight below the 10th centile for gestational age and sex on INTERGROWTH chart 5. Large for gestational age: birth weight above the 90th centile for gestational age and sex on INTERGROWTH chart 6. Caesarean section: surgical delivery of baby (emergency or elective) | — |
Secondary
| Measure | Time frame |
|---|---|
| All outcomes collected from routine maternity records following birth: 1. Gestational hypertension: blood pressure =140/90 mmHg on two occasions at least 4 hours apart after 20 weeks gestation 2. Late-term birth: pregnancy that extends over 41 weeks gestation 3. Induction of labour: non-surgical treatment to induce the labour 4. Instrumental delivery: an assisted birth when forceps or a ventouse suction cup is applied 5. Retained placenta: as reported in medical records 6. Haemorrhage: 3rd stage of labour and immediate postpartum period, measured in ml blood loss; as reported in medical records 7. Maternal infection: as reported in medical records 8. Fetal growth: measured at 2nd and 3rd trimester scans, including: 8.1. 2nd trimester scan: fetal head circumference; fetal abdominal circumference; fetal femur length; estimated fetal weight Hadlock; as reported in medical records 8.2. 3rd trimester scan: abdominal circumference; femur length; estimated fetal weight Hadlock; umbilical artery PI; end diastolic flow; amniotic fluid index; as reported in medical records 9. Apgar scores at 1 and 5 minutes (score 1-10): as reported in medical records 10. Respiratory distress (including requiring resuscitation): as reported in medical records 11. Feeding method (first feed and feed method at discharge): breastfeeding or artificial feed; as reported in medical records 12. Admission to neonatal special care baby unit (SCBU) or intensive care unit (NICU), high-dependency care, transitional care: as reported in medical records | — |
Countries
England, United Kingdom
Outcome results
None listed