Prevention of enteric infections and tungiasis in children and soil-transmitted helminthiasis in all ages living in rural Kenya Infections and Infestations
Conditions
Interventions
The flooring intervention will involve retrofitting a cement-stabilised floor that is sealed, washable and durable and that covers the total interior floor space of a household dwelling. The intervent
(ii) possess good wear resistance
(iii) acceptable appearance
(iv) be affordable. The proposed structure will consist of a base layer made from compacted cement-stabilized murram and a final sand and cement mortar finish. All materials required to build the floo
Sponsors
London School of Hygiene & Tropical Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Resident in a household with a child under 5 years of age 2. Dwelling where child under 5 sleeps meet structural criteria (unimproved earthen flooring throughout, structurally sound) 3. All household members willing to temporarily relocate whilst floors are laid
Exclusion criteria
Exclusion criteria: 1. No child under 5 years of age resident in the household 2. Dwelling where a child aged under 5 years sleeps has improved floor (i.e. cement or tiled) or is not structurally sound 3. Household is intending to move within the next 12 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Enteric infections: Prevalence of enteric infections in children under 5 years old measured using PCR analysis of stool at baseline and 12 months after receiving the floors. Pathogens identified from those observed at baseline using a multipathogen panel on a subset of 100 samples. 2. Tungiasis infections: Prevalence of tungiasis (detected through clinical examination of hands and feet) in children under 15 years old at baseline and 12 months after receiving the floors. 3. STH infections: Prevalence of at least one STH infection (hookworm, acsaris and trichuris infections; detected through Kato Katz of stool samples) in all household members 12 months and older at baseline and 12 months after receiving the floors. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Gastrointestinal illness measured using caregiver-reported symptoms at baseline and 12 months 2. Severity of acute and chronic tungiasis-associated pathology in children 1 year assessed using Kato Katz at baseline and 12 months 6. Prevalence of hookworm infection in all household members >1 year assessed using Kato Katz at baseline and 12 months 7. Prevalence of Trichuris trichiura infection in all household members >1 year assessed using Kato Katz at baseline and 12 months 8. Contamination of floors with eggs, larvae, pupae and adults of T. penetrans, assessed through entomology soil surveys at 6 months | — |
Countries
Kenya
Outcome results
None listed