A trial of intraoperative 5-fluorouracil (5-FU) in primary glaucoma surgery: effects on long term intraocular pressure control and disease progression

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN81872640

Enrollment

367

Registered

2000-10-24

Start date

1995-09-01

Completion date

Unknown

Last updated

2018-02-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glaucoma Eye Diseases Glaucoma

Interventions

5-FU versus placebo

Eligibility

Inclusion criteria

Inclusion criteria: Patients who are deemed to have inadequate intraocular pressure control in one or both eyes with or without medical treatment, who are listed for glaucoma filtration surgery by their consultant

Exclusion criteria

Exclusion criteria: 1. Anterior segment percutaneous versus aphakia 2. Previous glaucoma filtration surgery 3. Uveitis 4. Any previous intraocular surgery

Design outcomes

Secondary

Measure	Time frame
Changes in visual fields and optic disc cupping	—

Primary

Measure	Time frame
Levels of intraocular pressure following surgery	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026