Muscle mass loss and nutrition in critically ill children

A prospective observational study to explore the relationships between nuTRition, protein intake ANd muScle mass loss during and after Pediatric Intensive caRE

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN81803039

Enrollment

Registered

2021-09-08

Start date

2021-10-11

Completion date

Unknown

Last updated

2024-07-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Muscle mass loss during and after pediatric intensive care Musculoskeletal Diseases Muscle wasting and atrophy, not elsewhere classified

Interventions

The researchers will use a special ultrasound machine to look at a child’s thigh muscle (using gel and running a probe over the muscle, which does not hurt at all). The researchers will do this measur

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Invasively ventilated children (term neonate to 16 years) 2. Expected to stay >48 hours in PICU 3. Receiving some form of nutrition (enteral and/or parenteral) 4. Parents consent to the study 5. Normal neurologically 6. Of walking age 7. Independently ambulatory pre-admission 8. No previous PICU admission within the last 5 years 9. No known neuromuscular disease

Exclusion criteria

Exclusion criteria: Does not meet inclusion criteria

Design outcomes

Primary

Measure	Time frame
1. PICU muscle wasting assessed using ultrasound at days 1, 3, 5, 7 and 10 of PICU stay, hospital discharge and 3 months 2. Protein intake during critical illness assessed using nitrogen balance (g/day) from admission to PICU discharge	—

Secondary

Measure	Time frame
1. Energy intake during critical illness assessed using electronic hospital records from admission to PICU discharge 2. Nitrogen balance during critical illness assessed using routine dietician calculations from admission to PICU discharge 3. Inflammatory markers (CRP) that relate to the severity of illness, measured using routinely collected blood tests over the PICU stay 4. Muscle wasting and function changes assessed using ultrasound during PICU admission and from PICU discharge to 3 months after PICU discharge 5. Risk factors for PICU-muscle wasting assessed using history and electronic hospital records during PICU stay 6. Length of ventilation, PICU length of stay, and hospital length of stay assessed using electronic hospital records at PICU and hospital discharge 7. Functional physical state (FSS) assessed using FSS score at PICU and hospital discharge and at 3 months 8. Muscle function recovery assessed using Bayley’s motor score, MFM 20 or MFM 32 at PICU and hospital discharge and at 3 months 9. Quality of life assessed using PedsQL at 3 months after PICU discharge	—

Measure

Time frame

1. Energy intake during critical illness assessed using electronic hospital records from admission to PICU discharge 2. Nitrogen balance during critical illness assessed using routine dietician calculations from admission to PICU discharge 3. Inflammatory markers (CRP) that relate to the severity of illness, measured using routinely collected blood tests over the PICU stay 4. Muscle wasting and function changes assessed using ultrasound during PICU admission and from PICU discharge to 3 months after PICU discharge 5. Risk factors for PICU-muscle wasting assessed using history and electronic hospital records during PICU stay 6. Length of ventilation, PICU length of stay, and hospital length of stay assessed using electronic hospital records at PICU and hospital discharge 7. Functional physical state (FSS) assessed using FSS score at PICU and hospital discharge and at 3 months 8. Muscle function recovery assessed using Bayley’s motor score, MFM 20 or MFM 32 at PICU and hospital discharge and at 3 months 9. Quality of life assessed using PedsQL at 3 months after PICU discharge

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Countries

England, United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026