Critical illness and delirium Other
Conditions
Interventions
This trial has been designed as a feasibility study to inform a future definitive randomised controlled trail
exploring trial recruitment and retention, feasibility and acceptability of data collection procedures, and outcome measures, intervention fidelity and evidence of efficacy.
In standard care for this
Sponsors
University Hospitals Plymouth NHS Trust
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Adults (aged 18 years and above) 2. Unplanned admission to ICU within 48 hours of admission 3. Mechanically ventilated, with a clinical view it will be for >48 hours 4. Plan to start enteral feeding (providing nutrition via a tube into the gastrointestinal tract) or enteral feeding has commenced during the daytime only so far 5. Likely to require enteral feeding for >48 hours
Exclusion criteria
Exclusion criteria: 1. Planned admissions unless unexpectedly ventilated during the first 24 hours of admission 2. Continuous enteral feeding already commenced overnight (22:00-08:00) 3. Known intolerance to enteral feeding or currently unable to absorb enteral feed 4. Post-emergency bowel surgery 5. Type 1 diabetes or pre-existing insulin therapy (with risk of significant dysglycaemia on fasting for 10 hours) 6. Hyponatraemia; serum Na <115 mmol/L 7. Nil-by-mouth 8. Clinician considers daytime-only feeding unsuitable for the patient 9. Pregnancy and breastfeeding 10. Post-pyloric feeding via jejunostomy tube 11. Receiving parenteral nutrition 12. Dementia, psychosis, bipolar disorder and pre-existing use of antipsychotic drugs (haloperidol, olanzapine, quetiapine) or alcohol use, daily and to excess 13. Prone position ventilation
Countries
England, United Kingdom
Contacts
Public ContactTim Macdonald
Outcome results
None listed