Propofol versus Propofol plus Hydrocodone sedation in flexible bronchoscopy

Propofol versus Propofol plus Hydrocodone sedation in flexible bronchoscopy: a prospective, randomised, placebo-controlled, double-blind study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN81533083

Enrollment

300

Registered

2010-06-10

Start date

2009-02-14

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sedation for flexible bronchoscopy Surgery

Interventions

Patients were randomly assigned to either intravenous propofol or the combination of propofol and hydrocodone (4mg).

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age > 18 years 2. Requirement of flexible bronchoscopy 3. Written informed consent

Exclusion criteria

Exclusion criteria: 1. Tracheal Intubation 2. Known allergy or intolerance to hydrocodone or propofol 3. Mental retardation 4. Pregnancy

Design outcomes

Primary

Measure	Time frame
Cough score during the procedure as estimated by the physician using a visual-analogue-scale (VAS)	—

Secondary

Measure	Time frame
1. Total dose of propofol 2. Haemodynamic parameters 3. Patient?s discomfort, assessed 2 hours after procedure 4. Complications during flexible bronchoscopy 5. Patient reported side effects, assessed 24 hours after procedure	—

Countries

Switzerland

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026