Epithelial corneal defects, created iatrogeniccally during surface laser ablation procedure Eye Diseases Epithelial corneal defects, created iatrogeniccally during surface laser ablation procedure
Conditions
Interventions
Patients serve as their own control, with one eye randomly allocated to receive D-panthenol in propyl-methyl-cellulose eye drops four times daily for 2 months, and the other to receive carboxy methyl
Sponsors
The Eye Consultants Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Ametropia 2. Seeking laser vision correction 3. Best corrected visual acuity 20/20 or better in each eye 4. Eyes fit for laser ablation procedure and otherwise normal
Exclusion criteria
Exclusion criteria: 1. Previous ocular surgery 2. Concomitant ocular morbidity
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of epithelial healing, assessed by: 1. Rate of epithelial closure, assessed on a slit lamp bio-microscope on days 1, 2 and 3 2. Corneal haze, assessed on a slit lamp bio-microscope at weeks 1, 2, 3 and 4, and the end of month 2 | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Effect of D-panthenol on visual acuity, assessed by: 1.1. Uncorrected visual acuity (UCVA) using a Snellen's chart at days 1, 2 and 3, weeks 1, 2, 3 and 4, and the end of month 2 1.2. Residual subjective refraction, assessed using an auto-refractometer at weeks 1, 2, 3, and 4, and the end of month 2 2. Subjective comfort with or without D-panthenol, assessed by asking participants to rate comfort out of 5, with 0 indicating "no discomfort" and 5 being "severe intolerant symptoms", at weeks 1, 2, 3 and 4, and the end of month 2 | — |
Countries
Saudi Arabia
Outcome results
None listed