Infertility in females undergoing PGS cycles Urological and Genital Diseases Female infertility
Conditions
Interventions
The study would be structured as follows:
1. Ovarian stimulation by agonist or antagonist protocol
2. Ovum pick up performed 36 hours after human chorionic gonadotropin (HCG) administration
3. In vi
Sponsors
Genera Centre for Reproductive Medicine (Italy)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. All consecutive patients enrolled for blastocyst stage PGS cycles 2. Signed consent form
Exclusion criteria
Exclusion criteria: 1. Positive serology for hepatitis B or C or HIV 2. Persisting ovarian cysts > 30 mm diameter 3. Patient is a carrier of monogenic diseases or chromosomal abnormalities 4. Known American Society for Reproductive Medicine (ASRM) Grade III or IV endometriosis 5. Maternal disease that is not clinically stable and known to impact the ability to become pregnant or carry a pregnancy to term 5.1. Lupus 5.2. Chronic liver or kidney disease 5.3. Body mass index (BMI) greater than 30 5.4. Uncontrolled hypertension 5.5. Anti-phospholipid antibody 5.6. Thrombophilia 5.7. Insulin-dependent diabetes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ongoing implantation rate. It will be expressed as the number of blastocyst implanted (after 12 weeks) from the day of embryo transfer divided by the total number of blastocysts transferred. It will be updated up to 12 weeks from the last blastocyst transfer performed before the 01/12/2014. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Survival rate. It will be expressed as the number of surviving blastocysts after thawing divided by the total number of blastocysts thawed up to 01/12/2014. 2. Re-expansion rate within 3 hours post warming. It will be expressed as the number of blastocysts re-expanding within no more than 3 hours after thawing divided by the total number of blastocysts surviving to the warming procedure up to 01/12/2014. 3. Biochemical rate. It will be expressed as the number of transfers resulting in a ß-hCG positive test without a proper clinical pregnancy divided by the total number of transfers resulting in a ß-hCG positive test. It will be updated up to 2 weeks from the last blastocyst transfer performed before 01/12/2014. 4. Abortion rate. It will be expressed as the number of miscarriages divided by the total number of clinical pregnancies. It will be updated up to 12 weeks from the last blastocyst transfer performed before 01/12/2014. | — |
Countries
Italy
Outcome results
None listed