Combined Cognitive-Behavioral and Pharmacological Continuation and Maintenance Treatment of Recurrent Depression

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN81212636

Enrollment

168

Registered

2006-05-26

Start date

2006-06-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Recurrent depression Mental and Behavioural Disorders Depression

Interventions

Cognitive-behavioral continuation or maintenance therapy versus manualized active psychoeducation

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Diagnosis of recurrent depressive disorder (>3 major depressive episodes [MDE]), currently in remission (ICD-10 F33.4) 2. Complete remission over 8 weeks after acute treatment of MDE 3. At least one index depressive episode within 12 months prior to the treatment 4. Hamilton Rating Scale for Depression (HRSD-17) score of 9 or less over 8 weeks prior to treatment 5. Age 18-70 years

Exclusion criteria

Exclusion criteria: 1. Organic mental disorder 2. Psychological or behavioral disorders caused by psychotropic substances 3. Schizophrenia, schizoaffective disorder 4. Bipolar depression 5. Adjustment disorders 6. Borderline personality disorder 7. Mental retardation 8. Acute suicidality 9. Severe co-morbid medical condition 10. More than five individual sessions of regular cognitive-behavioral treatment within one year before randomization

Design outcomes

Primary

Measure	Time frame
Time to first relapse	—

Secondary

Measure	Time frame
Depression (Hamilton Rating Scale for Depression)	—

Countries

Germany

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026