A double-blind, randomised, controlled multicentre trial of three misoprostol regimens after pretreatment with mifepristone for termination of early pregnancy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN81170837

Enrollment

2100

Registered

2004-04-01

Start date

1998-09-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Induced abortion Pregnancy and Childbirth Abortion

Interventions

All women treated with a single dose of 200 mg mifepristone on Day 1. Day 3: Group A: 0.8 mg misoprostol orally and placebo tablets vaginally. Groups B and C: 0.8 mg misoprostol vaginally and placeb

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Healthy women 2. Eligible for and requesting medical abortion 3. Prepared to terminate the pregnancy should the treatment fail

Exclusion criteria

Exclusion criteria: No exclusion criteria

Design outcomes

Primary

Measure	Time frame
Three treatment regimens will be compared in terms of: 1. Their effectiveness to induce complete abortion 2. The frequency of side effects 3. The duration of bleeding Approximate duration of involvement in the study for each subject: second follow-up visit on day 43 post treatment, third follow-up visit if required	—

Secondary

Measure	Time frame
No secondary outcome measures	—

Countries

China, Finland, Hong Kong, Hungary, India, Mongolia, Norway, Romania, Singapore, Slovenia, Sweden, Viet Nam

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026