Helicobacter pylori infection after failed first treatment Digestive System Helicobacter pylori infection
Conditions
Interventions
Allocated the patients to two options of therapy:
1. Experimental: omeprazol 20 mg/12 hours and amoxicillin 1 gr/12 hours and rifabutin 150 mg/12 hours for seven days
2. Control therapy: omeprazol 20
Sponsors
Andalusian Digestive Disease Society (Sociedad Andaluza de Patología Digestiva) (Spain)
Eligibility
Inclusion criteria
Inclusion criteria: Patients in whom Helicobacter pylori infection persisted after a triple therapy treatment were included.
Exclusion criteria
Exclusion criteria: 1. Withheld consent 2. Had initially been treated by the "Test and Treat" procedure, or a baseline endoscopy was not obtained 3. Fulfilment of the treatment regimen and attendance at follow-up appointments could not reasonably be expected 4. Human Immunodeficiency Virus (HIV) positive status 5. Active alcoholism 6. Addiction to drugs 7. Age less than 18 years or more than 75 years 8. The suspicion of tuberculous infection 9. Either because of a positive intradermal reaction to Mantoux and compatible thorax radiography, or if the patient had previously received tuberculostatic treatment, or a known allergy to any of the components of either of the two treatment regimens 10. Received quadruple therapy as first-line treatment, or any other treatment including bismuth (e.g., ranitidine bismuth citrate), or antibiotics during the previous month 11. Severe associated diseases: a. cardiac insufficiency b. respiratory insufficiency c. chronic kidney insufficiency d. hepatic insufficiency e. advanced neoplasic diseases 12. Pregnant or lactating
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy assesed by urea breath test, measured 45 days after completion of the treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse events at the completion of the treatment, and 45 days after the completion of the treatment. | — |
Countries
Spain
Outcome results
None listed