Obesity Nutritional, Metabolic, Endocrine
Conditions
Interventions
This study includes bariatric surgery candidates with different degrees of intestinal malabsorption (gastric bypass, biliopancreatic derivation) or restriction (sleeve gastrectomy), according to the c
Sponsors
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos.
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Cases: 1. Men and women with ages between 18-65 years 2. BMI = 40 kg/m² (men) or = 35 kg/m² (women) with at least one major comorbidities (type 2 diabetes, hypertension, hyperlipemia, sleep obstructive apnea) 3. Absence of serious disease (chronic kidney disease, liver disease, neurological disease) 4. Absence of psychiatric pathology 5. Ability to understand the mechanisms involved in the surgery that will be proposed 6. Written informed consent to participate in the study Controls: 1. Men and women with ages between 18-65 years 2. BMI between 18.5-24.9 kg/m² 3. Absence of comorbidities 4. Absence of serious disease (chronic kidney disease, liver disease, neurological disease) 5. Absence of psychiatric pathology 6. Written informed consent
Exclusion criteria
Exclusion criteria: 1. Systematic disease not associated with obesity (inflammatory bowel disease, inflammatory rheumatic disease…) 2. Hepatitis C, known cirrhosis (or discovered during the study) 3. HIV 4. Drug and/or alcohol abuse 5. Eating disorders 6. Pregnancy or breastfeeding 7. Psychiatric disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Variation in weight response after bariatric surgery and the correlation with genetic variation. 1. Gene determinations (SNPS polymorphisms) measured using extraction of DNA from peripheral blood samples prior to surgery. The evaluation of the selected SNPs is analysed by allelic discrimination using Taqman® probes. 2. Weight, measured with calibrated electronic scale at 6 months, 1 year, 2 years, 3 years, 4 years, 5 years, 6 years, 7 years, 8 years, 9 years; Total weight loss percentage (TWLP), calculated by formula; excess weight loss percentage (EWLP), calculated by formula. Ideal weight calculated for BMI 25 kg/m2. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evolution of comorbidities after bariatric surgery and the correlation with genetic variation. 1. At the time of surgery: age, gender, ethnia, type of surgery, date of surgery, weight, height, BMI, presence of comorbidities (hypertension, diabetes, dyslipidemia, NAFLD, obstructive sleep apnoea syndrome). 2. Remission of comorbidities (hypertension, diabetes, dyslipidemia, NAFLD, obstructive sleep apnoea syndrome). | — |
Countries
Spain
Outcome results
None listed