Sickle cell anaemia (HbSS) Haematological Disorders Sickle-cell anaemia without crisis
Conditions
Interventions
The subjects, after stratification by age and gender, will be randomly assigned to receive coded and indistinguishable omega 3 (n=70) or placebo (n=70) capsules.
Subsequent to randomi
Sponsors
Mother and Child Foundation (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. HbSS phenotype 2. Male and female participants 3. Steady state 4. Aged 2 to 50 years old
Exclusion criteria
Exclusion criteria: 1. Other phenotypes 2. Patients in crisis 3. Patients on hydroxyurea treatment 4. Presence of other chronic diseases 5. Blood transfusion in the previous four months 6. Pregnancy 7. Previous history of overt stroke
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Annualised rates of clinical vaso-occlusive crisis is defined as painful events that lead to hospitalisation. 1.1. Vaso-occlusive crisis is defined as a painful event characterised by musculoskeletal and/or visceral pain which is usually associated with mild pyrexia and the passage of dark or red urine. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Haemolytic crisis 2. Rate of blood transfusion 3. School attendance 4. Hb level and mean cell volume (MCV) | — |
Countries
Sudan
Outcome results
None listed