Does bicarbonate of soda affect water balance when it is prescribed to treat people with kidney failure?

The effects of oral sodium bicarbonate on extracellular water in patients with chronic renal failure

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN80601080

Enrollment

Registered

2008-01-23

Start date

2007-06-06

Completion date

Unknown

Last updated

2019-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic kidney disease Urological and Genital Diseases Chronic kidney disease

Interventions

Oral sodium bicarbonate 1.5 g three times a day for 4 weeks versus placebo. Follow up is complete at the end of the 4-week treatment period.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Chronic kidney disease (CKD) (creatinine greater than 180 mcmol/l or glomerular filtration rate [GFR] less than 60 ml/min) 2. Aged over 18 years, male and female

Exclusion criteria

Exclusion criteria: 1. Need for dialysis 2. Already taking oral sodium bicarbonate 3. Uncontrolled hypertension 4. Peripheral oedema 5. Nephrotic syndrome 6. Congestive cardiac failure

Design outcomes

Primary

Measure	Time frame
Extracellular water and total body water measured by bromide space and deuterium dilution at 4 weeks.	—

Secondary

Measure	Time frame
The following will be assessed at 4 weeks: 1. Blood pressure 2. Bio-impedance measures of total body water (TBW) and extracellular fluid (ECF)	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026