Breath carbon monoxide measurement in jaundiced newborns

Early identification of hemolysis with ETCOc measurement in neonates at risk for severe hyperbilirubinemia

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN80570289

Enrollment

Registered

2018-07-20

Start date

2018-07-09

Completion date

Unknown

Last updated

2021-03-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neonatal hyperbilirubinemia (jaundice) Pregnancy and Childbirth Neonatal hyperbilirubinemia

Interventions

After written consent from parents, infants will have two measurements of breath carbon monoxide concentration, the first within 12-24 hours of enrolment and the second 12-24 hours following this. The

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Born or admitted in KK Women's and Children's Hospital 2. Gestational age of 35 weeks or more 3. Birth weight of 2000 g or more 4. Presence of jaundice and requiring phototherapy or presence of blood group incompatibility/G6PD deficiency

Exclusion criteria

Exclusion criteria: 1. Maternal history of smoking 2. Neonates requiring respiratory support

Design outcomes

Secondary

Measure	Time frame
Linear correlation between ETCOc values and the degree of hemolysis, as assessed using reticulocyte counts	—

Primary

Measure	Time frame
1. ETCOc (Corrected end-tidal carbon monoxide) values, measured with a CoSense capnometer device. Two measurements will be taken, the first 12-24 hours after recruitment and the second 12-24 following the first measurement. The following blood test measurements will be taken at the time of admission or later, as per the treating physician's discretion, and will be completed as per routine laboratory investigations: 2. Serum bilirubin 3. Blood counts 4. Reticulocyte counts 5. G6PD status 6. Blood group of mother and baby 7. Antibody titres 8. Coombs test results	—

Measure

Time frame

1. ETCOc (Corrected end-tidal carbon monoxide) values, measured with a CoSense capnometer device. Two measurements will be taken, the first 12-24 hours after recruitment and the second 12-24 following the first measurement. The following blood test measurements will be taken at the time of admission or later, as per the treating physician's discretion, and will be completed as per routine laboratory investigations: 2. Serum bilirubin 3. Blood counts 4. Reticulocyte counts 5. G6PD status 6. Blood group of mother and baby 7. Antibody titres 8. Coombs test results

—

Countries

Singapore

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026