Perinatal depression Mental and Behavioural Disorders
Conditions
Interventions
At assessment women will be classified as either having a history of depression or onset of depression in pregnancy. Antidepressant use is found to be a prognostic variable. Hence, at the recruitment
Sponsors
University of Surrey
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Pregnant women irrespective of age, ethnicity, socioeconomic status, pregnancy status (primigravida or multigravida) 2. Pregnant women may be prescribed an antidepressant or not 3. Pregnant women may be taking supplements or not
Exclusion criteria
Exclusion criteria: Women infected with HIV will be excluded. Whilst they are particularly susceptible to zinc deficiency, the HIV virus also requires zinc and excessive dietary zinc has been linked with declining CD4 cell counts and reduced survival. Baum et al. (2010) carried out a RCT of zinc supplementation to prevent immunological failure in HIV-infected adults and whilst no serious side effects were reported, the dose was significantly lower than the suggested therapeutic dose for this study. More research is needed; hence women who are HIV positive will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of depressive symptoms, measured using the Edinburgh Post Natal Depression Score at 6-12 weeks baseline, 20 weeks/anomaly scan, 28-30 weeks, birth visit up to 10 days post delivery, and 4 weeks post delivery | — |
Secondary
| Measure | Time frame |
|---|---|
| Measured at 6-12 weeks baseline, 20 weeks/anomaly scan, 28-30 weeks, birth visit up to 10 days post delivery, and 4 weeks post delivery: 1. Zinc levels in the blood, measured using a blood test 2. Zinc intake from diet, measured using the Zinc Food Frequency Questionnaire and 4-day food and drink diary | — |
Countries
United Kingdom
Outcome results
None listed