The impact of prehospital blood sampling on the emergency department process of patients with chest pain, a pragmatic non-randomized controlled trial

In patients who are transported to the emergency department with chest pain and no abnormalities at their prehospital ECG, what are the blood sample arrival times, troponin turnaround times, and length of stay of patients in whom prehospital blood draw is performed compared with controls in whom blood draw is performed at the emergency department? BCLOSED (Blooddraw Chestpain patients, impact on Length Of Stay at the Emergency Department)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN80335325

Enrollment

196

Registered

2022-01-09

Start date

2019-10-01

Completion date

Unknown

Last updated

2024-02-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with chest pain without abnormalities at their ECG, arriving at the ED by ambulance for cardiology Circulatory System

Interventions

Current interventions as of 03/05/2022: We conducted a pragmatic non-randomized controlled trial, comparing chest pain patients who underwent prehospital blood sampling with chest pain patients who w

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Current inclusion criteria as of 03/05/2022: 1. Patients with chest pain and no abnormalities at their ECG 2. Adult (18 years and older) 3. Transported by ambulance 4. Triage level 2 (orange) 5. Assessment by cardiology Previous inclusion criteria: 1. Patients with chest pain and no ST-elevation at their ECG 2. Adult (18 years and older) 3. Transported by ambulance 4. Triage level 2 (orange)

Exclusion criteria

Exclusion criteria: 1. Age <18 years 2. Not fulfilling inclusion criteria

Design outcomes

Primary

Measure	Time frame
All measured retrospectively: 1. Patient demographics: age and gender measured using hospital information system, through query 2. Patients’ medical history and risk factors for cardiac ischemic events (smoking history, diabetes mellitus, hypertension, dyslipidemia, prior cardiovascular disease, family history coronary disease) measured using reviewing patient notes in the hospital information system 3. Arrival time measured using hospital information system, through query 4. Troponin values measured using reviewing patient notes in the hospital information system 5. Whether or not the patient underwent radiology tests measured using hospital information system, through query 6. Disposition measured using hospital information system, through query 7. Time intervals: Blood sample arrival times at the laboratory were defined as the duration between patient arrival at the ED and blood sample arrival at the laboratory. Troponin turnaround time was defined as time between patient arrival at the ED and the availability of the troponin result in the hospital information system. ED LOS was defined as the time between the patient’s presentation at the ED and the time the patient left the ED to be admitted or discharged home measured using measured using hospital information system, through query 8. Whether the patient arrived during extreme busyness at the ED was measured with the NEDOCS, the National ED OverCrowding Score, a multidimensional scale to measure patient volume and hospital throughput measured using hospital information system, through query	—

Measure

Time frame

All measured retrospectively: 1. Patient demographics: age and gender measured using hospital information system, through query 2. Patients’ medical history and risk factors for cardiac ischemic events (smoking history, diabetes mellitus, hypertension, dyslipidemia, prior cardiovascular disease, family history coronary disease) measured using reviewing patient notes in the hospital information system 3. Arrival time measured using hospital information system, through query 4. Troponin values measured using reviewing patient notes in the hospital information system 5. Whether or not the patient underwent radiology tests measured using hospital information system, through query 6. Disposition measured using hospital information system, through query 7. Time intervals: Blood sample arrival times at the laboratory were defined as the duration between patient arrival at the ED and blood sample arrival at the laboratory. Troponin turnaround time was defined as time between patient arrival at the ED and the availability of the troponin result in the hospital information system. ED LOS was defined as the time between the patient’s presentation at the ED and the time the patient left the ED to be admitted or discharged home measured using measured using hospital information system, through query 8. Whether the patient arrived during extreme busyness at the ED was measured with the NEDOCS, the National ED OverCrowding Score, a multidimensional scale to measure patient volume and hospital throughput measured using hospital information system, through query

—

Secondary

Measure	Time frame
Current secondary outcome measures as of 03/05/2022: 1. Number of blood sample mix-ups 2. Blood sample quality (hemolysis and insufficient blood) Previous secondary outcome measures: There are no secondary outcome measures	—

Countries

Netherlands

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026