Sleep quality in critically ill patients on proportional assist ventilation with load-adjustable gain factors (PAV+) vs pressure support (PS)

Sleep quality in critically ill patients on proportional assist ventilation with load-adjustable gain factors (PAV+) vs pressure support (PS) - a randomised controlled cross-over trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN80274260

Enrollment

Registered

2009-11-11

Start date

2009-10-25

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sleep quality in critically ill patients on mechanical ventilation Respiratory

Interventions

Patients will be connected to an ICU ventilator (Puritan-Bennett® 840), able to ventilate them with PS and PAV. Polysomnography will be performed in each patient as previously described for 24 hours s

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Critically ill patients (>18 years old, both males and females) who are receiving mechanical ventilation for at least 48 hours will be studied. At the time of the study all patients will be haemodynamically stable and ventilated on PS through cuffed endotracheal or tracheostomy tubes with anticipated further mechanical ventilation of at least 24-h duration. All patients must achieve a score of 0 on the Richmond Agitation Sedation Scale (RASS) either with or without intravenous (IV) propofol.

Exclusion criteria

Exclusion criteria: 1. Anticipated ICU stay 13 5. General anesthetic, drug overdose, or alcohol intoxication within the preceding 24 h

Design outcomes

Primary

Measure	Time frame
Effect of PAV and PS in sleep quality.	—

Secondary

Measure	Time frame
Patient - ventilator interaction during sleep. Flow (V?), volume (V), airway pressure (Paw), end-tidal CO2 (PETCO2), the motion of the rib cage and abdomen, inspiratory (TI) and expiratory (TE) time, total respiratory cycle time (TTOT) and peak inspiratory airway pressure (Pawpeak) will be measured on a breath-by breath basis, while coefficient of variation of tidal volume (VT) and TTOT will be calculated.	—

Measure

Time frame

Patient - ventilator interaction during sleep. Flow (V?), volume (V), airway pressure (Paw), end-tidal CO2 (PETCO2), the motion of the rib cage and abdomen, inspiratory (TI) and expiratory (TE) time, total respiratory cycle time (TTOT) and peak inspiratory airway pressure (Pawpeak) will be measured on a breath-by breath basis, while coefficient of variation of tidal volume (VT) and TTOT will be calculated.

—

Countries

Greece

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026