Multimorbidity, polypharmacy and frailty Other
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: Physician–pharmacist pairs (general practitioners and community pharmacists) 1. Both professionals working within the same Primary Care Team Network (CPTS), with shared patient care 2. Managing patients aged 75 years and older with polypharmacy (defined as taking five or more medications) 3. General practitioners working either: - In private practice (solo or group practices, or multi-professional health centers), or - In salaried positions (e.g., municipal health centers) 4. Pharmacists working in community pharmacies (either solo or in group settings) 5. Both GPs and pharmacists must provide informed consent to participate 6. All participants must be located within one of the identified CPTS areas (see list of participating investigator centers)
Exclusion criteria
Exclusion criteria: 1. General practitioners and pharmacists not working together in daily practice (i.e., not jointly managing patients) 2. Professionals not involved in the care of patients aged 75 years or older with polypharmacy (defined as taking five or more medications) 3. General practitioners with specific alternative modes of practice, such as acupuncture, allergology, or homeopathy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in inappropriate medication prescriptions following the physician–pharmacist medication review intervention. Inappropriate prescriptions are defined as: Overuse: Presence of a drug with insufficient clinical benefit (low or no added therapeutic value); Misuse: Use of a drug associated with a high risk of serious adverse effects; Underuse: Absence of an indicated medication that should have been prescribed. The outcome will be assessed by comparing the appropriateness of prescriptions before and after the structured medication reconciliation session between the general practitioner and the pharmacist | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Barriers and facilitators to interprofessional collaboration between general practitioners and pharmacists during the medication reconciliation session. Areas of interest include: - Professional organisation - Interprofessional communication - Collaboration and professional boundaries - Patient pathologies and behaviours - Social and societal factors 2. Feasibility and acceptability of the intervention, assessed by: 2.1. Participation rate of GPs and pharmacists: monitored throughout the inclusion period 2.2. Average time per medication review: reported by participants after each session via a brief log 2.3. Reasons for failure or non-completion: documented in structured logs 2.4. Perceived usefulness, strengths/weaknesses, and practicality: assessed via a post-intervention questionnaire 2.5. Optional semi-structured interviews may be conducted with some participants to explore their experience in more depth 3. Satisfaction level of the professionals involved (GPs and pharmacists) with the intervention, based on structured feedback | — |
Countries
France