Panic disorder with and without agoraphobia Mental and Behavioural Disorders Panic disorders
Conditions
Interventions
Two treatment conditions are compared, both of them state-of-the-art-CBT:
Condition A: CBT for panic disorder with therapist-guided in-vivo exposure exercises (in-vivo cBT-group)
Sponsors
German Federal Ministry of Education and Research (Bundesministerium Für Bildung und Forschung [BMBF]) (Germany)
Eligibility
Inclusion criteria
Inclusion criteria: 1. Outpatients 2. 18 to 65 years old 3. Meet current Diagnostic and Statistical Manual of Mental Disorders - Fourth Edition (DSM-IV) criteria of panic disorder with/without agoraphobia 4. Hamilton Anxiety Scale (HAMA) score more than or equal to 18 and a Clinical Global Impressions scale (CGI) score more than or equal to four 5. Able to attend clinic on his/her own or accompanied by significant others 6. Informed consent to participate and follow study procedures
Exclusion criteria
Exclusion criteria: 1. DSM-IV Axis I diagnoses of any psychotic disorder, bipolar disorder, current alcohol or drug dependence and Axis II of borderline personality disorder 2. DSM-IV Axis I disorders (other than panic disorder and agoraphobia) currently treated either by medications or non-pharmacological intervention 3. Acute suicidality (Composite International Diagnostic Interview [CIDI] scale 2+) 4. General medical contraindications
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Number of panic attacks/month 2. Aggregated Panic Disorder Scale and Mobility Inventory (PDS-MI) score (panic severity plus avoidance) 3. Hamilton Anxiety Rating Scale | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Depressive symptoms 2. Anticipatory anxiety in dark room-challenge and time in darkroom 3. Psychophysiological parameters 4. Neuroimaging parameters 5. Ecological Momentary Assessment (EMA) parameters | — |
Countries
Germany
Outcome results
None listed