The ability of anti-dandruff shampoo to reduce dandruff, itching, scalp histamine, and scalp microbiome in subjects with moderate to severe dandruff

The effect of anti-dandruff shampoo on scalp dandruff, itch, histamine, and microbiome

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN79977393

Enrollment

Registered

2024-11-27

Start date

2024-12-07

Completion date

Unknown

Last updated

2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Moderate to severe dandruff Skin and Connective Tissue Diseases

Interventions

Interventions: anti-dandruff shampoo containing selenium sulfide, selenium sulfide and piroctone olamine, and placebo Randomization: simple randomization Details of interventions: Shampooing 3 times a

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Had not undergone menopause for female 2. Have Adherent Scalp Flaking Score (ASFS) of = 24 at the baseline visit 3. Comply with the procedure, agree to complete the study, and provide written informed consent

Exclusion criteria

Exclusion criteria: 1. Having scalp diseases or scalp scarring 2. Having history of contact dermatitis at the scalp 3. Having difficulties in verbal and written communication 4. Having difficulties in mobility 5. Using medication of oral anti-fungal, immunosuppressant agents, anti-inflammatory, or chronic antihistamine drugs within 4 weeks prior to baseline 6. Using medication of anti-dandruff, anti-psoriatic, or anti-seborrhoeic dermatitis shampoos within 2 weeks prior to baseline; and any other significant medical condition

Design outcomes

Primary

Measure	Time frame
Scalp dandruff measured using Adherent Scalp Flaking Score (ASFS) at baseline, day 14, and 28	—

Secondary

Measure	Time frame
1. Itch intensity measured using Worst Itching Intensity-Numerical Rating Scale (WI-NRS) at baseline, day 14, and 28 2. Scalp histamine levels or inflammation markers measured using ELISA at baseline and day 28 3. Scalp microbiome measured using Nanopore® Next Generation Sequencer at baseline and day 28	—

Countries

Indonesia

Contacts

Public ContactArum Krismi

dr_arumkrismi@staff.ukdw.ac.id+62 811254861

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026