Infertility Urological and Genital Diseases Female infertility
Conditions
Interventions
In a non-randomised pilot study of an unselected population (50 patients), an increase in live birth rate biochemical pregnancy rate of 15% was observed in the intervention group compared with a contr
Sponsors
Liverpool Women’s NHS Foundation Trust
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. All women undergoing fresh or frozen embryo transfer 2. All women able to provide written informed consent
Exclusion criteria
Exclusion criteria: 1. Known or suspected hydrosalpinx 2. Fluid within the endometrial cavity 3. Gross distortion of endometrium (e.g. fibroids etc) 4. Previous myomectomy 5. Previous randomization 6. Significant health issues, e.g. HIV, Hepatitis C, Hepatitis B, previous trachelectomy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Live births, recorded at follow up at 10 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Biochemical pregnancy, defined as urinary pregnancy test positive, at 2 weeks after embryo transfer 2. Clinical pregnancy, defined as presence of intrauterine pregnancy with fetal heart rate >100bpm between 6-8 weeks pregnancy, at 5 weeks after embryo transfer 3. Miscarriage, recorded at 20 weeks after embryo transfer 4. Ectopic pregnancy, recorded at 8 weeks after embryo transfer 5. Multiple pregnancies, recorded at 5 weeks after embryo transfer 6. Failed embryo transfer, recorded at time of procedure 7. Grading of ease of procedure (Easy 1 to Difficult 5), recorded at time of procedure 8. Duration of procedure, recorded at time of procedure 9. Patient experience, assessed by questionnaire following procedure | — |
Countries
England, United Kingdom
Contacts
Public ContactLewis;Louise Nancarrow;Hardman
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Outcome results
None listed